2002 4cylinder escape issue
 

Hello all, my name is Mark and I'm new to the forum. I have an issue that started the other day where my 2002 escape started running very poorly. I used my brothers code reader and got a P0301 misfire in cylinder 1 reading. I found that the #1 spark plug had actually loosened a little. Weird?! I changed all of the plugs and it ran better but now when I give it gas to accelerate between gears (manual tranny) it starts missing again but if I just ease up on the gas a little it will smooth out. Even when the cruise is on and I come to a rise in the road it will miss on the way up and then smooth out at the top. I then changed a couple of vacuum hoses in poor condition and also the throttle position sensor...still the same thing. I also get the P0301 code again. Anyone have any ideas on this?? Thanks!!