I have a 2014 F250 Super Duty. When I'm driving down the highway at anywhere between speeds 65 and 75 I get a loud wind noise in the cab sounding like a horn. I thought it might be the windshield not sealing properly. I have closed all the vents and still get the noise I mean it is so loud you can hardly talk over the noise, has anyone else had this issue and how did you fix it?

 

Check the doors all around. If you think it's at the windshield you can remove the roof liner and test with a pressure washer.