I’m looking to buy a used F350 for the purpose of overland camping. I found one that seems to fit and already has all terrain tires. One thing bothers me, it’s had the universal joint replaced four times and the driveshaft once or twice. I don’t know what to make of this. Your thoughts?

Thanks!

The truck:
https://www.autotrader.com/cars-for-sale/vehicledetails.xhtml?listingId=586767596&listingTy pes=Used&startYear=2014&makeCode1=FORD&modelCode1= F350&LNX=CRMVDPCCEML

 

The lift on the truck might explain why it's going through universal joints - when you lift a truck, it changes pinion angles, which can put more stress on the u-joint....
If the universal joint failed catastrophically (the driveshaft came free at speed or during a high-torque event) the shaft can bang against the ground, bending it.
If I were to own the truck and want to remedy the situation, I'd probably check to ensure that the pinion angles match up with the output of the transfer case; you can cut the hangers on the axle and true things up a bit (But make sure your differential and pinion gears still get oil); more than likely, I'd remove the lift and return it to stock.
Otherwise, carry spare u-joints, learn to inspect them regularly, and learn to change them in the field (I've only had a u-joint fail on me on my old *****'s CJ-5; I removed the rear driveshaft and drove back home on just the front).